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LEAF(TM) Purified anti-mouse IL-23 (p19)

LEAF(TM) Purified anti-mouse IL-23 (p19)

Cat no: 513806

Supplier: BioLegend
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IL-23 is a member of the IL-12 family of cytokines, and the p19-p40 heterodimer is stabilized by a disulfide bond. The subunit p40 is shared by IL-23 and IL-12 cytokines. p19 mRNA is expressed in endothelial cells and polarized T cells; nevertheless, p40 is not expressed by these cells. Therefore, the availability of functional IL-23 is limited by the expression of p40 and not p19. IL-23 induces IFN-gamma production from T cells treated with PHA. IL-23 exerts its biological activities through the interaction with a heterodimeric receptor complex composed of IL-12Rb1 and IL-23R. IL-23 activates Janus kinase (JAK)/signal transducer and activator of transcription signaling molecules (STAT). JAK2 is constitutively associated with the IL-23R chain, and binding of IL-23 to its receptor leads to phosphorylation of STAT1, STAT3, STAT4, and STAT5. IL-23 plays a key role in the pathogenesis of autoimmunem and its role in chronic inflammatory disorders is supported by the identification of IL-23 receptor (IL-23R) susceptibility alleles associated with inflammatory bowel disease, psoriasis, and ankylosing spondylitis.
Catalogue number: 513806
Reactivities: Mouse
Hosts: Mouse
Applications: Block/Neutralize/Inhibit
Size: 500 microg
Clone: MMp19B2
Gene: 83430
Dilutions: Each lot of this antibody is quality control tested by blocking activity of mouse IL-23 (5 ng/ml) in mouse splenocytes.
Storage buffer: The antibody solution should be stored undiluted at 4C. This LEAF(TM) solution contains no preservative; handle under aseptic conditions.
Concentration: 1 mg/ml
Antigen: Mouse p19 C-terminal peptide
Isotype: Mouse IgG2b, kappa
Clonality: Monoclonal
Regulatory status: RUO
Shipping temp: Ambient RT
Storage temp: 4 C
Alternative names: Interleukin-23 p19
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