LEAF(TM) Purified anti-mouse LAP (TGF-beta1)

Cat no: 141304

Supplier: BioLegend

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Transforming growth factor beta (TGF-beta) is a cytokine that has critical functions in immune response by regulating Treg and Th17 cells. TGF-beta is first synthesized as pro-TGF-beta and then it is cleaved by furin proprotein convertase in the Golgi apparatus to produce the dimeric propeptides called latency-associated peptide (LAP) that non-covalently associates with the dimeric mature TGF-beta to prevent its activity. This complex can further associate with latent-TGF-beta-binding protein (LTBP) to produce a large latent form for deposition onto the extracellular matrix. The latent-TGF-beta can be expressed on the membrane of activated Treg cells, immature dendritic cells, megakaryocytes, and platelets.

Catalogue number:	141304
Reactivities:	Mouse
Hosts:	Mouse
Applications:	Flow Cytometry, Immunoprecipitation, Western Blot
Size:	500 microg
Clone:	TW7-20B9
Gene:	21803
Dilutions:	Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is ?1.0 microg per million cells in 100 microl volume or 100 microl of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Storage buffer:	The antibody solution should be stored undiluted at 4C. This LEAF(TM) solution contains no preservative; handle under aseptic conditions.
Concentration:	1 mg/ml
Antigen:	Mouse Tgfb1-transduced P3U1 cells
Isotype:	Mouse IgG1, kappa
Clonality:	Monoclonal
Regulatory status:	RUO
Shipping temp:	Ambient RT
Storage temp:	4 C
Alternative names:	TGFB, TGFB1, DPD1, Latency Associated Peptide (LAP), TGF-beta1, TGF-beta

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LEAF(TM) Purified anti-mouse LAP (TGF-beta1)

Cat no: 141304

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