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LEAF(TM) Purified anti-mouse/rat CD61

LEAF(TM) Purified anti-mouse/rat CD61

Cat no: 104310


Supplier: BioLegend
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CD61 is a 110 kD integrin beta chain also known as beta3 integrin or gpIIIa. It associates with the integrin alphav chain (CD51) to form the vitronectin receptor. In addition, CD61 can associate with the integrin alphaIIb chain (CD41) to form the gpIIb/IIIa complex. CD61 is expressed on platelets, megakaryocytes, endothelium, smooth muscle, a subset of B cells, myeloid cells, osteoclasts, and mast cells. CD61, in conjunction with CD41 or CD51, mediates adhesion to fibronectin, fibrinogen, vitronectin, thrombospondin, and von Willebrand factor. Leukocyte-endothelial adhesion is mediated by the binding of alphav/beta3 integrin or vitronectin receptor to CD31 (PECAM-1).
Catalogue number: 104310
Reactivities: Mouse, Rat
Hosts: Hamster
Applications: Block/Neutralize/Inhibit, Flow Cytometry, Immunohistochemistry
Size: 500 microg
Clone: 2C9.G2 (HMbeta3-1)
Gene: 16416,29302
Dilutions: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is ? 0.25 microg per 106 cells in 100 microl volume. It is recommended that the reagent be titrated for optimal performance for each application.
Storage buffer: The antibody solution should be stored undiluted at 4C. This LEAF(TM) solution contains no preservative; handle under aseptic conditions.
Concentration: 1 mg/ml
Antigen: Vitronectin receptor protein from the mouse T-cell hybridoma 2B4
Isotype: Armenian Hamster IgG
Clonality: Monoclonal
Regulatory status: RUO
Shipping temp: Ambient RT
Storage temp: 4 C
Alternative names: beta3 integrin, Integrin beta3 chain, gpIIIa
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