LEAF(TM) Purified anti-mouse VEGFR-3 (FLT-4)

Cat no: 140904

Supplier: BioLegend

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Description
Additional Information

VEGFR-3, also known as FLT4, is a member of the Tyr protein kinase family. The extracellular portion of VEGFR-3 contains 7 immunoglobulin (Ig)-like domains and the cytoplasmic portion contains a protein kinase domain. FLT4 regulates angiogenesis and lymphangiogenesis, its ligands are VEGF-C and D and its binding is mediated by the 2nd and 3rd Ig-like domains of FLT4. During fetal development VEGFR-3 is expressed on endothelial cells, however, in the adult mice, the vascular endothelial cells lose VEGFR-3 expression, but the lymphatic endothelium expresses it constitutively. In addition, VEGFR-3 expression can be induced in tumors with active angiogenesis.

Catalogue number:	140904
Reactivities:	Mouse
Hosts:	Rat
Applications:	Block/Neutralize/Inhibit, ELISA, Immunohistochemistry, Immunoprecipitation, Western Blot
Size:	500 microg
Clone:	AFL4
Gene:	14257
Dilutions:	Each lot of this antibody is quality control tested by immunohistochemistry.?
Storage buffer:	The antibody solution should be stored undiluted at 4C. This LEAF(TM) solution contains no preservative; handle under aseptic conditions.
Concentration:	1 mg/ml
Antigen:	VEGFR-3-Fc fusion protein
Isotype:	Rat IgG2a, kappa
Clonality:	Monoclonal
Regulatory status:	RUO
Shipping temp:	Ambient RT
Storage temp:	4 C
Alternative names:	Vascular endothelial growth factor receptor 3, FLT-4, Fms-like tyrosine kinase 4