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SPECIFICATIONS
Price
323.00 USD
Catalog Number
CAC07199
Size
100 micro g
Applications
IF, IHC, WB
Hosts
Rabbit
Conjugates
Unconj
Purity
Protein G purified, >95%
Target
LEF1
Clonality
Polyclonal
Storage Temp
Aliquot and store at -20 degrees C. Minimize freezing and thawing.
Research Area
For research use only. Not for diagnostic procedures.
Shipping Temp
Blue ice
Additional Info
Participates in the Wnt signaling pathway. Activates transcription of target genes in the presence of CTNNB1 and EP300. May play a role in hair cell differentiation and follicle morphogenesis. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by LEF1 and CTNNB1. Regulates T-cell receptor alpha enhancer function. Binds DNA in a sequence-specific manner. PIAG antagonizes both Wnt-dependent and Wnt-independent activation by LEF1 (By similarity). Isoform 3 lacks the CTNNB1 interaction domain and may be an antagonist for Wnt signaling. Isoform 5 transcriptionally activates the fibronectin promoter, binds to and represses transcription from the E-cadherin promoter in a CTNNB1-independent manner, and is involved in reducing cellular aggregation and increasing cell migration of pancreatic cancer cells. Isoform 1 transcriptionally activates MYC and CCND1 expression and enhances proliferation of pancreatic tumor cells.
Alternative Names
Lymphoid enhancer-binding factor 1LEF-1,T cell-specific transcription factor 1-alpha,TCF1-alpha,LEF1
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