An immunosuppressive. Inhibits T and B cell proliferation. Activity is attributed mainly to its metabolite, a malononitrile derivative, which is beleived to inhibit dihydroorotate dehydrogenase as well as several protein tyrosine kinases.
Source:
Synthetic
Purity:
~90%
Form:
Supplied as an off-white crystalline solid
Melting Point:
159-161 degrees C
Solubility:
Chloroform, Methanol
Method for Determining Identity:
Proton NMR and Mass Spectroscopic Analysis.
TLC Conditions:
SiO2: Hexane: Ethyl Acetate; 3:2; Visualized with UV and KMnO4; Single spot; Rf=0.6.
Storage and Stability:
May be stored at RT for short-term only. Long-term storage is recommended at -20 degrees C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
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