Fibrinogen-like protein 2 (FGL2), also known as fibroleukin, was first cloned from cytotoxic T lymphocytes and was classified as a member of the fibrinogen superfamily due to its homology (36%) with fibrinogen b and g chains. In humans, the fgl2 gene encodes a protein of 439 amino acids. Under non-reducing conditions, the molecular mass of the protein is 250-300 kD and in reducing conditions, it is 64-70 kD, indicating that FGL2 in its natural state forms a tetrameric complex. It is postulated that FGL2 has pleiotropic effects and is an important immune regulator of both innate and adaptive responses. In macrophages and endothelial cells, FGL2 is expressed as a membrane-associated protein, which acts as a prothrombinase enzyme with the ability to generate thrombin directly from prothrombin. FGL2 also exists as a secreted form expressed by regulatory T cells that down-regulates dendritic cell activity and induces B cell apoptosis. The regulatory activity of FGL2 has been implicated in inhibition of allograft rejection, autoimmunity, and the pathogenesis of experimental as well as human viral infections. BioLegend's Human FGL2 LEGEND MAX(TM) ELISA Kit is a Sandwich Enzyme-Linked Immunosorbent Assay (ELISA) with 96 well microtiter strip plates that are pre-coated with a capture antibody. This Human FGL2 ELISA Kit with pre-coated plates is specifically designed for the accurate quantitation of analytes from cell culture supernatant, serum, plasma, and other biological fluids. This kit is analytically validated, with ready-to-use reagents.
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