Human IL-22 (IL-10-related T cell-derived inducible factor) is produced by activated T cells and acts on nonimmune cells to regulate local tissue inflammation. As a product of the TH17 lineage of CD4+ effector lymphocytes, IL-22 plays a critical role in mucosal immunity as well as in the disregulated inflammation observed in autoimmune diseases. IL-22's biological activity is initiated by binding to a cell surface complex composed of IL-22R1 and IL-10R2 receptor chains and further regulated by interactions with the soluble binding protein IL-22BP that share sequence similarity with an extracellular region of IL-22R1 (sIL-22R1). Both chains of the IL-22R complex are members of the class II cytokine receptor family. Two types of IL-22 binding receptors have been discovered, a membrane-bound receptor and a soluble receptor, both encoded by different genes. BioLegend's LEGEND MAX(TM) Human IL-22 ELISA Kit is a sandwich Enzyme- Linked Immunosorbent Assay (ELISA), in which, a Human IL-22 specific polyclonal antibody is pre-coated on a 96-well strip-well plate. BioLegend's LEGEND MAX(TM) Human IL-22 ELISA Kit is specifically designed for the accurate quantitation of Human IL-22 from cell culture supernatant, serum, plasma or other bodily fluids. It is ready-to-use, accurate, and sensitive.
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