Human IL-27 is a member of the IL-12 cytokine family and is a heterodimeric protein composed of EBI3 (Epstein-Barr virus-induced gene 3) and p28 protein. It is expressed on naïve CD4+ T cells and natural killer cells. IL-27 is produced by antigen-presenting cells to induce proliferation of naive CD4+ T cells and activates human monocytes via STAT1 in addition to suppressing IL-10 production. IL-27 mediates its biological effects through the orphan cytokine receptor WSX-1/TCCR. IL-27 strongly synergizes with IL-12 to support IFN-gamma production and differentiation of naive CD4+ T cells into T helper type.BioLegend’s LEGEND MAX(TM) Human IL-27 ELISA Kit is a sandwich Enzyme-Linked Immunosorbent Assay (ELISA), in which, a Human IL-27 specific monoclonal antibody is pre-coated on a 96-well strip-well plate.BioLegend’s LEGEND MAX(TM) Human IL-27 ELISA Kit is specifically designed for the accurate quantitation of Human IL-27 from cell culture supernatant, serum, plasma or other bodily fluids. It is ready-to-use, accurate, and sensitive.
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