Interleukin-28 (IL-28, IFN-lambda2, IFN- lambda3) is a class II cytokine receptor ligand distantly related to type I interferons (IFNs) and the IL-10 family. IL-28 has two isoforms,IL-28A (IFN-lambda2) and IL-28B (IFN-lambda3) that are similar in amino acid sequence to IL-29 (IFN-lambda1), as IL-29 shows 81% homology with IL-28A. IL-28 and IL-29 are produced by human peripheral blood mononuclear cells and dendritic cells upon viral infection, LPS stimulation, TLR stimulation, stimulation with poly(I:C) and other inducers of type I interferons. IL-28 and IL-29 both play a role in the interferon-mediated immune defense against viruses and up-regulate MHC class I antigen expression. BioLegend’s LEGEND MAX(TM) Human IL-28A ELISA Kit is a sandwich Enzyme-Linked Immunosorbent Assay (ELISA), in which a Human IL-28A specific monoclonal antibody is pre-coated on a 96-well strip-well plate.BioLegend’s LEGEND MAX(TM) Human IL-28A ELISA Kit is specifically designed for the accurate quantitation of Human IL-28A from cell culture supernatant, serum, plasma or other bodily fluids. It is ready-to-use, accurate, and sensitive.
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