Myeloperoxidase (MPO) is a peroxidase enzyme which is expressed in neutrophils and macrophages. MPO is a 150 kD dimeric protein which consists of two 15 kD light chains and two variable weight glycosylated heavy chains bound to a prosthetic heme group. Three isoforms have been identified, differing in the size of the heavy chain. Mature human MPO shares 88% amino acid sequence identity with dog, mouse, and rat. Human MPO also shares 71%, 56%, and 47% amino acid sequence identity with comparable regions of human eosinophil peroxidase, lactoperoxidase, and thyroid peroxidase, respectively. MPO is released extracellularly, and it has been detected in a wide range of acute and chronic inflammatory conditions. Serum levels of myeloperoxidase (MPO) are associated with coronary artery disease and indicate a risk factor for pancreatic cancer. The LEGEND MAX(TM) Human Myeloperoxidase ELISA kit is a Sandwich Enzyme-Linked Immunosorbent Assay (ELISA) is a 96-well strip plate, pre-coated with a monoclonal capture antibody. This kit is specifically designed for the accurate quantitation of human MPO from cell culture supernatant, serum, plasma, saliva, urine and other biological fluids. This kit is analytically validated with ready-to-use reagents.
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