Interferon-beta is a member of the type I interferon class. Type I IFNs are involved in the innate immune system, being released non-specifically during the early stage of infection in response to stimuli such as viruses, dsRNA, LPS, and bacterial components. Once secreted by virus-infected or activated cells, they bind to the IFNalpha/beta receptor (IFNAR), which is found on almost all cell types. Then, via the JAK-STAT pathway, they induce the expression of hundreds of IFN-stimulated genes (ISGs). While the function of many of these proteins remains to be elucidated, a hallmark of type I IFNs is their anti-viral activities, both general and specific against particular viruses. Type I IFNs also regulate cell growth and apoptosis, and exert various immunomodulatory and inflammatory effects. As such, they are clinically relevant, both as therapeutics and as targets of inhibition for the treatment of various autoimmune diseases and cancer. Mouse IFN-beta is a ~20 kD monomeric glycoprotein. It has 50% amino acid sequence homology with mouse IFN-alpha, its closest related protein, and 62% homology with human IFN-beta. IFN-beta is currently the therapeutic of choice for treating multiple sclerosis. BioLegend’s LEGEND MAX(TM) Mouse IFN-beta ELISA Kit is a sandwich Enzyme-Linked Immunosorbent Assay (ELISA), in which, a specific antibody is pre-coated on a 96-well strip-well plate. BioLegend’s LEGEND MAX(TM) Mouse IFN-beta ELISA Kit is specifically designed for the accurate quantitation of mouse IFN-beta from cell culture supernatant, serum, plasma or other bodily fluids. It is ready-to-use, accurate, and sensitive.
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