Thymic stromal lymphopoietin, also known as TSLP, is a hemopoietic cytokine originally identified as a product of a thymic stromal cell line (Z210R.1). Mouse TSLP is a 24 kD, monomeric glycoprotein which belongs to the IL-7 family of cytokines. TSLP is produced mainly by non-hematopoietic cells such as fibroblasts, epithelial cells and stromal or stromal-like cells. In mice, TSLP is reported to impact B cell maturation at different stages in vitro. TSLP is also involved in expanding the CD4+ subset of lymphocytes and thymocytes and thus regulate CD4+ cell homeostasis. In humans, TSLP mainly impacts myeloid cells and induces the release of T cell-attracting chemokines from monocytes and enhances the maturation of CD11c+ dendritic cells. TSLP activated dendritic cells prime naïve T cells into a Th2 phenotype, which are strong producers of cytokines IL-13, IL-5, and TNF-alpha. TSLP also stimulates the production of Th2 cytokines by human mast cells. Therefore, TSLP acts on multiple targets and has broad roles in the regulation of inflammatory and allergic processes.
BioLegend’s LEGEND MAX(TM) Mouse TSLP ELISA Kit is a sandwich Enzyme-Linked Immunosorbent Assay (ELISA), in which, a Mouse TSLP specific monoclonal antibody is pre-coated on a 96-well strip-well plate.BioLegend’s LEGEND MAX(TM) Mouse TSLP ELISA Kit is specifically designed for the accurate quantitation of Mouse TSLP from cell culture supernatant, serum, plasma or other bodily fluids. It is ready-to-use, accurate, and sensitive.
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