Rat IL-17A, also known as IL-17 and Cytotoxic T Lymphocyte-Associated Antigen-8 (CTLA-8), is a founding member of the IL-17 family of cytokines. IL-17 is mainly produced by Th17 cells, a small subset of T helper cells. IL-17 exhibits multiple biological activities including the induction of various proinflammatory cytokines and chemokines such as IL-6, IL-8, G-CSF, GM-CSF, GRO-alpha, and MCP-1 on a variety of cell types. IL-17 is also involved in the activation of NF-kB and costimulation of T cell proliferation. As a result of these roles, IL-17 has been linked to many immune and autoimmune-related diseases including rheumatoid arthritis, asthma, lupus, and multiple sclerosis. BioLegend’s Rat IL-17A LEGEND MAX(TM) ELISA Kit is a Sandwich Enzyme-Linked Immunosorbent Assay (ELISA) with 96 well microtiter strip plates that are precoated with a capture antibody. This kit is specifically designed for the accurate quantitation of rat IL-17A from cell culture supernatant, serum, plasma and other biological fluids. This kit is analytically validated, with ready-to-use reagents.
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