Human leptin (Anti-Obesity Protein) is the human homologue of murine leptin, the protein product of the ob (obese) gene in mice which seems to be involved in appetite control. The murine ob gene is expressed in adipose tissue and is thought to regulate the body's fat stores. It targets the central nervous system, particularly hypothalamus, affecting food intake. Mice with the ob/ob genotype also develop a form of diabetes similar to type II (non-insulin dependent) diabetes. Human leptin is a 16.0kD protein containing 147 amino acid residues.
Source: E. coli
Specificity: Recombinant human leptin is 100% homologous with the human serum leptin.
Form: Sterile filtered and lyophilized from 0.5mg/ml in 10mM sodium citrate, pH 4.0
Purity: (same/more than) 95% by SDS-PAGE
Protein Content: 0.1mg (determined by BCA method)
Concentration: ~0.5mg/ml Protein
Endotoxin: 0.1ng/ug (1EU/ug)
Quality Control: BCA
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