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Leptomycin A (Antibiotic ATS 1287A, Antibiotic PD 118607, Jildamycin)

Cat no: L1671-38


Supplier: United States Biological
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Leptomycin A, a methyl (cf. ethyl) analogue of Leptomycin B, is a minor component of the leptomycin complex produced by selected Streptomyces species. Leptomycin B is a potent inhibitor of the nuclear transport receptor CRM1. Leptomycin A is also likely to inhibit nuclear transport and may offer differences in exporter selectivity. Leptomycin A shows antimicrobial activity against Schizosaccaromyces pombe and Mucor rouxianus. Purity: >99% by HPLC Solubility: Soluble in ethanol or methanol. Ethanol recommended. Unstable in DMSO. Related to: Anguinomycin A, Leptomycin B, Kazusamycin A, Kazusamycin B,
Catalogue number: L1671-38
Size: 100ug
Purity: >99% by HPLC
Alternative names: Antibiotic ATS 1287A, Antibiotic PD 118607, Jildamycin
References: 1. Leptomycins A and B, new antifungal antibiotics. I. Taxonomy of the producing strain and their fermentation, purification and characterization. Hamamoto T. et al. J. Antibiot. 1983, 36, 639. 2. Leptomycins A and B, new antifungal antibiotics. II. Structure elucidation. Hamamoto T. et al. J. Antibiot. 1983, 36, 646. 3. Leptomycin B, an inhibitor of the nuclear export receptor CRM1, inhibits COX-2 expression. Jang B.C. et al. J. Biol. Chem. 2003, 278, 2773.

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