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Products Leptomycin B (Elactocin, Antibiotic ATS 1287B, Antibiotic CI 940, Antibiotic CL 1957A, Antibiotic PD 114720, Mantuamycin)
| Catalogue number: | L1671-38A |
| Size: | 500ug |
| Form: | Colorless film |
| Purity: | >99% by HPLC |
| Alternative names: | Elactocin, Antibiotic ATS 1287B, Antibiotic CI 940, Antibiotic CL 1957A, Antibiotic PD 114720, Mantuamycin |
| References: | 1. Leptomycin B, an inhibitor of the nuclear export receptor CRM1, inhibits COX-2 expression. Jang B.C. et al. J. Biol. Chem. 2003, 278, 2773. 2. Leptomycin B inhibition of signal-mediated nuclear export by direct binding to CRM1. Kudo N. et al. Exp. Cell. Res. 1998, 242, 540. 3. Nuclear-cytoplasmic shuttling of C-ABL tyrosine kinase. Taagepera S. et al. Proc. Natl. Acad. Sci. USA 1998, 95, 7457. 4. CRM1 is responsible for intracellular transport mediated by the nuclear export signal. Fukuda M. et al. Nature 1997, 390, 308. |
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