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Leptomycin B (Elactocin, Antibiotic ATS 1287B, Antibiotic CI 940, Antibiotic CL 1957A, Antibiotic PD 114720, Mantuamycin)

Cat no: L1671-38A

Leptomycin B (Elactocin, Antibiotic ATS 1287B, Antibiotic CI 940, Antibiotic CL 1957A, Antibiotic PD 114720, Mantuamycin)

Leptomycin B is the dominant and most studied member of the leptomycin class isolated from selected Streptomyces strains. Leptomycin B is a nanomolar active and specific nuclear export inhibitor. Its target is CRM1/exportin1 a protein in the nuclear export sequence (NES). Examples of proteins affected are c-Abl, cyclin B1, HIV-1 Rev, IkB, MPF, MAP/ERK, MDM2/p53, NF-kB/IkB7 and PKA. Export of many RNAs are also inhibited e.g. COX-2 and c-FOS mRNA. In addition Leptomycin B shows antifungal and antibacterial and potent antitumour activities.\n\nPurity: >99% by HPLC\n\nForm: Colorless film\n\nSolubility: Soluble in ethanol or methanol. Ethanol is recommended. Unstable in DMSO.\n\nStorage and Stability: Stable for 6 months at -20 degrees C.\n\nRelated to: Anguinomycin A, Leptomycin A, Kazusamycin A, Kazusamycin B

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SPECIFICATIONS

Catalog Number

L1671-38A

Size

500ug

Form

Colorless film

Purity

>99% by HPLC\n

References

1. Leptomycin B, an inhibitor of the nuclear export receptor CRM1, inhibits COX-2 expression. Jang B.C. et al. J. Biol. Chem. 2003, 278, 2773. 2. Leptomycin B inhibition of signal-mediated nuclear export by direct binding to CRM1. Kudo N. et al. Exp. Cell. Res. 1998, 242, 540. 3. Nuclear-cytoplasmic shuttling of C-ABL tyrosine kinase. Taagepera S. et al. Proc. Natl. Acad. Sci. USA 1998, 95, 7457. 4. CRM1 is responsible for intracellular transport mediated by the nuclear export signal. Fukuda M. et al. Nature 1997, 390, 308.

Alternative Names

Elactocin, Antibiotic ATS 1287B, Antibiotic CI 940, Antibiotic CL 1957A, Antibiotic PD 114720, Mantuamycin

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