Supplier:
Alomone Labs Ltd.Cat no: L-500
Leptomycin B
In the late 90пїЅs Leptomycin B, was found as inhibitor of the nucleo-cytoplasmic translocation process of the HIV-1 Rev protein and Rev-dependent mRNA at nanomolar concentrations and was the first low molecular weight inhibitor of nuclear export to be identified.
The target molecule of Leptomycin B has been shown by genetic and biochemical analyses to be CRM1, a highly conserved protein in eukaryotes. CRM1 was shown to be a member of the importin beta family and a receptor for the nuclear export signal (NES) of proteins in both yeast and mammalian cells. Leptomycin B binds directly to CRM1, which results in the dissociation of the NES from the nuclear export machinery containing CRM1 and leads to the nuclear accumulation of many proteins in both yeast and mammalian cells.
Thus, Leptomycin B serves as a potent tool for understanding the molecular mechanisms of nucleo-cytoplasmic transport of proteins. Cell Signaling Activators and Inhibitors; Protein Synthesis and Transport Inhibitors.
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SPECIFICATIONS
Catalog Number
L-500
Size
5 x 1micro g
Purity
>98%
Concentration
1-50 nM
Shipping Temp
Room Temperature
Molecular Weight
540.75
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