Leuprolide, Human ([des-Gly10, D-Leu6, Pro-NHEt9]-LH-RH)

Synthetic Human Leuprolide is a single, non-glycosylated, polypeptide chain containing 9 amino acids and having a molecular mass of 1209 Dalton.\n\nSequence :\nGlu-His-Trp-Ser-Tyr-DLeu-Leu-Arg-Pro-NHEt.\n\nReconstitution:\nReconstitute the lyophilized Leoprolide in sterile 18MOmega-cm H2O not less than 100ug/ml, which can then be further diluted to other aqueous solutions.\n\nStorage and Stability:\nLyophilized powder may be stored at 4 degrees C for short-term only. Reconstitute to nominal volume by adding sterile dH2O and store at -20 degrees C. Reconstituted product is stable for 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

L2051-02

Size

5mg

Form

Supplied as a lyophilized powder. No additives.

Purity

(same/more than) 95% by RP-HPLC, FPLC, or reducing/non-reducing SDS-PAGE Silver Stain. Chromatographically purified.

References

1. A single luteinizing hormone determination 2 hours after depot leuprolide is useful for therapy monitoring of gonadotropin-dependent precocious puberty in girls. Brito VN, Latronico AC, Mendonca BB, J Clin Endocrinol Metab 2004 Sep;89(9):4338-42 2. Bicalutamide monotherapy versus leuprolide monotherapy for prostate cancer: effects on bone mineral density and body composition. Smith MR, Goode M, McGovern FJ, J Clin Oncol 2004 Jul 1;22(13):2546-53 3. Preparation, characterization, and biodistribution study of technetium-99m -labeled leuprolide acetate-loaded liposomes in Ehrlich ascites tumor-bearing mice. Arulsudar N, Subramanian N, Chuttani K, AAPS PharmSci 2004 Feb 06;6(1):E5 4. Transport of leuprolide across rat intestine, rabbit intestine and Caco-2 cell monolayer. Guo J, Ping Q, Dong J, Li C, Int J Pharm 2004 Jul 8;278(2):415-22 5. Control of musth in an Asian elephant bull (Elephas maximus) using leuprolide acetate. de Oliveira CA, West GD, Leblanc M, J Zoo Wildl Med 2004 Mar;35(1):70-6 6. Neoadjuvant hormone treatment with leuprolide acetate depot 3.75 mg and cyproterone acetate, before radical prostatectomy: a randomized study. Prezioso D, Lotti T, Montironi R, Urol Int 2004;72(3):189-95.