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Lipc, Recombinant, Mouse, aa291-510, His-tag (Hepatic Triacylglycerol Lipase, HL, Hepatic Lipase, Lipase Member C, Hpl, AI256194)

Lipc, Recombinant, Mouse, aa291-510, His-tag (Hepatic Triacylglycerol Lipase, HL, Hepatic Lipase, Lipase Member C, Hpl, AI256194)

Cat no: 149780

Supplier: United States Biological
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Hepatic lipase, also known as LIPC, is a lipolytic enzyme synthesized and secreted by hepatocytes that bind extracellularly to the parenchymal and endothelial cell surfaces in the space of Disse. Clinical studies have shown that an inverse relationship exists between the LIPC activity in postheparin plasma and plasma HDL-C concentrations, suggesting that it can serve as a marker for cardiovascular disease risk and may serve as a target for therapy. The doublet observed in the SDS-PAGE is likely due to incomplete removal of the signal sequence. Source: Recombinant protein corresponding to mouse LIPC, fused to His-tag at C-terminal expressed in E.coli. Molecular Weight: ~26kD Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: Aliquot to avoid repeated freezing and thawing and store at -70 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: 149780
Size: 50ug
Form: Supplied as a liquid in 1X PBS, 0.1% SDS.
Purity: ~95%
References: 1. Olivecrona T and Bengtsson-Olivercrona G. Lipoprotein lipase and hepatic lipase. Curr. Opin. Lipidol. 1993; 4:187-96. 2. Jansen H, Verhoeven AJ, and Sijbrands EJ. Hepatic lipase: a pro- or anti-atherogenic protein? J. Lipid Res. 2002; 43:1352-62. 3. Applebaun-Bowden D, Haffner SM, Wahl PW, et al. Postheparin plasma triglyceride lipases. Relationships with very low density lipoprotein triglyceride and high density lipoprotein 2 cholesterol. Arterioschlerosis 1985; 5:273-82. 4. Guerra R, Wang J, Grundy SM, et al. A hepatic lipase (LIPC) allele associated with high plasma concentrations of high density lipoprotein cholesterol. Proc. Natl. Acad. Sci. USA 1997; 94:4532-7.

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