Lipc, Recombinant, Mouse, aa291-510, His-tag (Hepatic Triacylglycerol Lipase, HL, Hepatic Lipase, Lipase Member C, Hpl, AI256194)

Hepatic lipase, also known as LIPC, is a lipolytic enzyme synthesized and secreted by hepatocytes that bind extracellularly to the parenchymal and endothelial cell surfaces in the space of Disse. Clinical studies have shown that an inverse relationship exists between the LIPC activity in postheparin plasma and plasma HDL-C concentrations, suggesting that it can serve as a marker for cardiovascular disease risk and may serve as a target for therapy. The doublet observed in the SDS-PAGE is likely due to incomplete removal of the signal sequence.\n\nSource:\nRecombinant protein corresponding to mouse LIPC, fused to His-tag at C-terminal expressed in E.coli.\n\nMolecular Weight:\n~26kD\n\nApplications:\nSuitable for use in ELISA and Western Blot. Other applications not tested.\n\nRecommended Dilution:\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nAliquot to avoid repeated freezing and thawing and store at -70 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

149780

Size

50ug

Form

Supplied as a liquid in 1X PBS, 0.1% SDS.

Purity

~95%

References

1. Olivecrona T and Bengtsson-Olivercrona G. Lipoprotein lipase and hepatic lipase. Curr. Opin. Lipidol. 1993; 4:187-96. 2. Jansen H, Verhoeven AJ, and Sijbrands EJ. Hepatic lipase: a pro- or anti-atherogenic protein? J. Lipid Res. 2002; 43:1352-62. 3. Applebaun-Bowden D, Haffner SM, Wahl PW, et al. Postheparin plasma triglyceride lipases. Relationships with very low density lipoprotein triglyceride and high density lipoprotein 2 cholesterol. Arterioschlerosis 1985; 5:273-82. 4. Guerra R, Wang J, Grundy SM, et al. A hepatic lipase (LIPC) allele associated with high plasma concentrations of high density lipoprotein cholesterol. Proc. Natl. Acad. Sci. USA 1997; 94:4532-7.