Lipin-1 Antibody

Cat no: 251271

Supplier: ABBIOTEC

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Description
Additional Information

Phosphatidate phosphatase LPIN1 (lipin-1) plays important roles in controlling the metabolism of fatty acids at differents levels. Lipin-1 acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride,Porcinehosphatidylcholine and phosphatidylethanolamine biosynthesis in the reticulum endoplasmic membrane. Lipin-1 acts also as a nuclear transcriptional coactivator for PPARGC1A/PPARA to modulate lipid metabolism gene e, Xenopus/Amphibian,pression. Defects in lipin-1 are a cause of autosomal recessive acute recurrent myoglobinuria, also known as acute recurrent rhabdomyolysis. Recurrent myoglobinuria is characterized by recurrent attacks of rhabdomyolysis (necrosis or disintegration of skeletal muscle) associated with muscle pain and weakness and followed by e, Xenopus/Amphibian,cretion of myoglobin in the urine. Renal failure may occasionally occur. Onset is usually in early childhood under the age of 5 years.

Catalogue number:	251271
Reactivities:	Human, Mouse, Porcine, Rabbit
Applications:	Immunohistochemistry
Size:	0.1 mg
Accession:	Q14693
Antigen:	KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human lipin-1.
Format:	Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
P type:	Rabbit Polyclonal Antibody
Isotype:	Rabbit Ig
Additional info:	Lipin-1; LPIN1; KIAA0188