Lipoxygenase is a family of non-heme, iron-containing enzymes. Most of these enzymes catalyze the dioxygenation of polyunsaturated fatty acids with cis,cis-1,4-pentadiene structures, synthesizing cell signaling molecules. These signaling molecules play various roles: they act as autocrine signals to regulate their parent cells, paracrine signals to regulate nearby cells, and endocrine signals to regulate distant cells.
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