Supplier:
Alomone Labs Ltd.Cat no: L-125
Lomerizine dihydrochloride
Lobeline hydrochloride is a lipophylic alkaloid which either agonizes or antagonizes the nicotine-evoked response of nAChRs. LObeline acts as an anxiolytic, a cognition enhancer and a neurotransmitter-release stimulant in the CNS, whereas it inhibits the response to ACh at the (A)7 subunit with an IC50 of 8.5 micro M, and decreases the endplate potential at the neuromuscular junction - thus attenuates locomotor sensitization. Moreover, its high affinity (Ki = 4-20 nM) to the (A)4(B)2, nAChR subtype, along with a nonselective binding to monoamine transporters, renders it capable of preventing the psychostimulatory effects of drugs of abuse.
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SPECIFICATIONS
Catalog Number
L-125
Size
100 mg
Purity
>99%
Concentration
0.1-100 uM.
Shipping Temp
Room Temperature
Molecular Weight
541.5 Da.
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