Luteinizing Hormone Releasing Hormone, Human (LHRH)

Synthetic Human LHRH is a single, non-glycosylated, polypeptide chain containing 10 amino acids and having a molecular mass of 1182.4 Dalton.\n\nSequence:\nGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-ProGly-NH2\n\nReconstitution:\nReconstitute the lyophilized LHRH in sterile 18MOmega-cm H2O not less than 100ug/ml, which can then be further diluted to other aqueous solutions.\n\nStorage and Stability:\nLyophilized powder may be stored at 4 degrees C for short-term only. Reconstitute to nominal volume by adding sterile dH2O and store at -20 degrees C. Reconstituted product is stable for 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

L7510-39

Size

10mg

Form

Supplied as a lyophilized powder. No additives.

Purity

(same/more than) 95% by RP-HPLC, FPLC, or reducing/non-reducing SDS-PAGE Silver Stain. Chromatographically purified.

References

1. Luteinizing hormone-releasing hormone fusion protein vaccines block estrous cycle activity in beef heifers. Stevens JD, Sosa JM, Oatley JM, J Anim Sci 2005 Jan;83(1):152-9 2. Possible role of phosphatidylinositol 4,5 bisphosphate in luteinizing hormone releasing hormone-mediated M-current inhibition in bullfrog sympathetic neurons. Ford CP, Stemkowski PL, Eur J Neurosci 2004 Dec;20(11):2990-8 3. Effects of PYY3-36 upon Luteinizing Hormone-Releasing Hormone and Gonadotropin Secretion in Prepubertal Rats: In Vivo and In Vitro Studies. Fernandez-Fernandez R, Aguilar E, Pinilla L, Endocrinology 2004 Nov 24; 4. Induction of apoptosis by AN-152, a cytotoxic analog of luteinizing hormone-releasing hormone (LHRH), in LHRH-R positive human breast cancer cells is independent of multidrug resistance-1 (MDR-1) system. Gumlnthert AR, Grumlndker C, Nagy A, Breast Cancer Res Treat 2004 Oct;87(3):255-64 5. Internalization of cytotoxic analog AN-152 of luteinizing hormone-releasing hormone induces apoptosis in human endometrial and ovarian cancer cell lines independent of multidrug resistance-1 (MDR-1) system. Gunthert AR, Grundker C, Schlott T, Am J Obstet Gynecol 2004 Oct;191(4):1164-72 6. A relapse in pedophilic sex offending and subsequent suicide attempt during luteinizing hormone-releasing hormone treatment. Briken P, Hill A, J Clin Psychiatry 2004 Oct;65(10):1429.