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Luteoreticulin (Griseulin)

Cat no: L7512-50

Luteoreticulin (Griseulin)

Luteoreticulin is a rare nitrophenyl pyranone closely related to aureothin, neoaureothin and its unusual photoisomers Antibiotics SNF4435C and D. Metabolites within this class have been shown to be potent antitumor agents with pronounced immunosupressive activity and more recently, the ability to reverse multi-drug resistence. The lack of availability of luteoreliculin has hitherto restricted a more intensive investigation of this interesting metabolite with publications relating only to the metabolite's isolation and chemistry.\n\nDMSO and DMF, partially soluble in methanol and ethanol while poorly soluble in water

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SPECIFICATIONS

Catalog Number

L7512-50

Size

500ug

Form

Pale yellow solid

Purity

>99%

References

1. The structure of luteoreticulin, a nitro-containing metabolite of Streptomyces luteoreticuli. Koyama Y. et al. Tetrahedron Lett. 1969, 5, 355. 2. High-performance liquid chromatography comparison of supercritical-fluid extraction and solvent extraction of microbial fermentation products. Cocks S. et al. J Chromatogr A. 1995, 697, 115. 3. Reversal of multidrug resistance by novel nitrophenyl pyrones, SNF4435C and D. Kurosawa K. Jpn. J. Cancer Res. 2001, 92, 1235.

Alternative Names

Griseulin

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