LY-294,002 (2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one)

Potent, cell permeable, highly specific PI(3)K (phosphoinositide 3-kinase) inhibitor. Acts on the ATP-binding site of the enzyme. Antagonizes P-glycoprotein-mediated multidrug resistance. Blocks Akt phosphorylation. Pim-1 kinase inhibitor.\n\nStorage and Stability:\nShort-term Storage: +4 degrees C\nLong-term Storage: -20 degrees C\nStable for at least 2 years after receipt when stored at -20 degrees C.

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SPECIFICATIONS

Catalog Number

045027

Size

1mg

Purity

>99% (NMR)

References

Product Reference: \n?A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4- morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002): C.J. Vlahos, et al.; J. Biol. Chem. 269, 5241 (1994)\n?Investigation of neutrophil signal transduction using a specific inhibitor of phosphatidylinositol 3-kinase: C.J. Vlahos, et al.; J. Immunol. 154, 2413 (1995)\n?Pim-1 Ligand-bound Structures Reveal the Mechanism of Serine/Threonine Kinase Inhibition by LY294002: M.D. Jacobs, et al.; J. Biol. Chem. 280, 13728 (2005)\n?LY294002 and LY303511 Sensitize Tumor Cells to Drug-Induced Apoptosis via Intracellular Hydrogen Peroxide Production Independent of the Phosphoinositide 3-Kinase-Akt Pathway: T.W. Poh & S. Pervaiz; Cancer Res. 65, 6264 (2005)\n?LY294,002, a specific inhibitor of PI3K/Akt kinase pathway, antagonizes P-glycoprotein-mediated multidrug resistance: M. Barancík, et al.; Eur. J. Pharm. Sci. 29, 426 (2006)\n?A role for Akt in the rapid regulation of inflammatory and apoptotic pathways in mouse bladder: F.J. Tamarkin, et al.; Naunyn Schmiedebergs Arch. Pharmacol. 373, 349 (2006)\n?Synthesis and biological evaluation of sulfonylhydrazone-substituted imidazopyridines as novel PI3 kinase p110alpha inhibitors: M. Hayakawa, et al.; Bioorg. Med. Chem. 15, 5837 (2007)\n?

Alternative Names

2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one