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LY 294002

Cat no: L-300

LY 294002

A Specific Inhibitor of PI 3-Kinase

PI 3-kinase is an enzyme implicated in growth factor signal transduction by associating with receptor and non-receptor tyrosine kinases. LY-294002 is a potent and specific cell-permeable inhibitor of Pl 3-kinase that acts on the ATP-binding site of the enzyme. In in vitro assays it displays an IC50 of 1.4 μM on purified PI 3-kinase, but did not inhibit 10/PKC, 10/PKA, MAP kinase and PI 4-kinase. In fMet-Leu-Phe stimulated neutrophils, LY-294002 completely abolished PI 3-kinase activity at 50 μM. LY-294002 induces apoptosis in many cell types by blocking the PI3-K/Akt anti-apoptotic pathway. Thus LY-294002 is useful tool for identifying the biochemical events regulated by the PI3-K/Akt pathway. This pathway has important relevance to the cellular events involved in cancer.

Protein Kinase Inhibitors and Activators; PI3-Kinase Inhibitors

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SPECIFICATIONS

Catalog Number

L-300

Size

10 x 0.25 mg

Purity

>99%

Concentration

5 - 10 micro M.

Shipping Temp

Room Temperature

Molecular Weight

307.35

SUPPLIER INFO

Alomone Labs Ltd.

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