Lypressin

Lypressin is a hormone used to prevent or control the frequent urination, increased thirst, and loss of water associated with diabetes insipidus (water diabetes). Its molecular weight is 1056.2 having an amino acid sequence of Cys-Tyr-Phe-Gln-Asn-Pro-Lys-Gly-NH2.\n\nDimers and Aggregates: \nLess than 1% as determined by silver-stained SDS-PAGE gel analysis.\n\nEndotoxin: \n(same/less than) 0.1ng/ug (IEU/ug) of Lypressin.\n\nSolubility: \nIt is recommended to reconstitute the lyophilized Lypressin in sterile 18MOmega-cm H2O not less than 100microg/ml, which can then be further diluted to other aqueous solutions.\n\nStability: \nLyophilized Lypressin although stable at room temperature for 3 weeks, should be stored desiccated below -180C. Upon reconstitution Lypressin should be stored at 40C between 2-7 days and for future use below -180C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please avoid freeze-thaw cycles.

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SPECIFICATIONS

Catalog Number

L8052-25

Size

5mg

Form

Supplied as a lyophilized powder without additives.

Purity

(same/more than) 98% as determined by RP-HPLC, anion-exchange FPLC and/or reducing and non-reducing SDS-PAGE Silver Stained gel.

References

1. Human pain thresholds after the application of lypressin, a vasopressin analogue.\n\nPharmacol Toxicol 1987 Jul;61(1):16-9\n\n2. [Influence of antianginal drugs on Lypressin induced T-wave enhancement in the electrocardiogram of the rat]\n\nArzneimittelforschung 1986 Oct;36(10):1454-7\n\n3. The effect of 6-hydroxydopamine and some hypotensive drugs on lypressin induced hypertension in rats.\n\nPol J Pharmacol Pharm 1985 Jul-Aug;37(4):487-93\n\n4. Lypressin (Diapid) and other drugs for diabetes insipidus.\n\nMed Lett Drugs Ther 1972 Dec 22;14(26):98-9\n\n5. Lypressin nasal spray. Usefulness in patients who manifest allergies to other antidiuretic hormone preparations.\n\nJAMA 1968 Feb 26;203(9):802-3\n\n6. [The state of plasma corticosteroids during insulin induced hypoglycemia and the effects of lypressin on the function of the hypothalamo-pituitary-adrenal axis]\n\nActa Endocrinol (Copenh) 1967 Aug;55(4):622-36