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Macrophage Colony Stimulating Factor (M-CSF)

Cat no: M1201-05B

Macrophage Colony Stimulating Factor (M-CSF)

Human Monocyte Colony Stimulating Factor (M-CSF) is a dimeric glycoprotein. M-CSF monomers are dimerized via disulfide-linkage and are glycosylated. M-CSF is produced by\nvarious cells such as monocytes, granulocytes, endothelial cells and fibroblasts. After cell activation, B-cells and T-cells and many tumor cell lines also produce M-CSF. M-CSF is a\nhematopoietic growth factor responsible for the survival and proliferation of monocytes\nand macrophages and for the differentiation of monocytes into macrophages. Additionally MCSF\nsynergises with other cytokines such as IL-3 and IL-6 for inducing the proliferation and\nthe differentiation of primitive hematopoietic cells into macrophages. M-CSF induces the synthesis of G-CSF, IFN, TNF, n and prostaglandins. M-CSF has been implicated in a variety of diseases, including atherosclerosis, lupus nephritis, and some cancers.\n\nApplications:\nSuitable for use in ELISA and Western Blot. \nOther applications have not been determined.\n\nRecommended Dilutions:\nWestern Blot: 0.5-2ug/ml\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nLyophilized powder may be stored at -20 degrees C. Stable for 6 months at -20 degrees C. Reconstitute with sterile ddH2O. Aliquot and store at -20 degrees C. Reconstituted product is stable for 1 month at 4 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

M1201-05B

Size

100ug

Applications

WB

Hosts

Rabbit

Reactivities

Hum

Form

Supplied as lyophilized powder from PBS, 0.02% sodium azide. Reconstitute with sterile PBS or H2O to 1mg/ml.

P Type

Pab

Purity

Purified by Protein A affinity chromatography.

Isotype

IgG

Additional Info

Recogizes human M-CSF.

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