Macrophage Inflammatory Protein 1 alpha, Recombinant, Human (CCL3, Chemokine (C-C Motif) Ligand 3, G0/G1 Switch Regulatory Protein 19-1, G0S19-1, G0S19-1 Protein, LD78ALPHA, MIP1A, MIP-1-alpha, PAT 464.1, SCYA3, SIS-beta, Small Inducible Cytokine A3 Precu

Macrophage Inflammatory Protein-1 (MIP-1,alpha) is part of the CC subfamily of the chemokine superfamily of chemoattractant cytokines. MIP-1& alpha affects the inflammatory response of blood monocytes, tissue macrophages, and T cells. MIP-1,alpha also enhances the formation of granulocyte-macrophage colonies stimulated by GM-CSF or M-CSF. Human MIP-1,alpha is composed of 69 aa residues with not possible N-linked glycosylation sites, and several possible O-linked sites. Human MIP-1,alpha is 60% homologous with human MIP-1, alpha, 75% homologous with murine MIP-1,alpha, and has been shown to be active on murine cells.\n\nBiological Activity:\nThe biological activity of recombinant human MIP-1 alpha is determined by its use as a cofactor for CSF-dependent myelopoiesis.\n\nStorage and Stability:\nFor long-term storage, aliquot to avoid repeated freezing and thawing and freeze at -70 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquots are stable for 6 months.

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SPECIFICATIONS

Catalog Number

M1202-04B

Size

10ug

Form

Supplied as a liquid in sterile ddH2O.

Purity

Purified by sequential chromatography. (same/more than)95% pure by SDS gel electrophoresis with low endotoxin.

References

1. Nathan, C.F. (1987)J. Clin. Invest. 79:319 2. Wolpe S.D. et al. (1989) Proc. Natl. Acad. Sci. (USA) 86:612 3. Tekamp-Olson. P. et al. (1990) J. Exp. Med. 172:911 4. Dunlop, et al (1992) Blood 79: 2221 5. Suzuki, K. et al. (1989) J. Exp. Med. 169:1895