MAGE 1, Recombinant, Human (Antigen MZ2-E, MAGE1A, MAGEA1, Melanoma Antigen 1, Melanoma Associated Antigen MZ2-E, MGC9326)

Human malignant neoplasms carry rejection antigens that are recognized by the patients autologous, tumor directed and specific, cytolytic, CD8+T lymphocyte clones (CTL). An important group of antigens is coded by the MAGE family of genes. It was identified that melanomas and primary glial brain tumors express common melanoma associated antigens (MAAs). Because MAGE-1 is expressed on a significant proportion of human neoplasms of various histological types (melanoma, brain tumors of glial origin, neuroblastoma, non-small cell lung cancer, breast, gastric, colorectal, ovarian, renal cell carcinomas) and not on mormal tissues, the encoded antigen may serve as a marker of early detection and target for cancer immunotherapy.\n\nRecombinant Human MAGE1 produced in E. coli is a disulfide-linked monomeric, non-glycosylated, polypeptide chain containing 200aa and having a molecular mass of 22.7kD.\n\nCharacterization: \nMAGE-1 antibody reactive.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. For long-term storage, store at -20 degrees C. Aliquots are stable for at least 6 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

M1750-20

Size

2ug

Form

Supplied as a liquid in 50mM Tris-acetate, pH 7.5, 1mM EDTA and 20% glycerol.

Purity

Purified by standard chromatographic techniques.

References

1. HER-2, gp100, and MAGE-1 are expressed in human glioblastoma and recognized by cytotoxic T cells. Cancer Res 2004 Jul 15;64(14):4980-6. 2. Is MAGE-1 expression in metastatic malignant melanomas really helpful? Am J Surg Pathol 2004 Jul;28(7):883-8. 3. [Expression of MAGE-1 and MAGE-3 genes in gastric cancer and gastric biopsy tissues and its clinical significance] Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2004 May;20(3):310-3. 4. [Establishment of mouse melanoma B16 cell lines co-expressing MAGE-1 and EGFP] Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2004 Mar;20 (2):212-4. 5. Heat shock protein 70 / MAGE-1 tumor vaccine can enhance the potency of MAGE-1-specific cellular immune responses in vivo. Cancer Immunol Immunother 2004 Sep;53(9):825-34. 6. Identification of a MAGE-1 peptide recognized by cytolytic T lymphocytes on HLA-B*5701 tumors. Tissue Antigens 2004 May;63(5):453-7.