Magic™ Anti-C4c Complement polyclonal antibody

Rabbit anti-Human C4c Complement polyclonal antibody for IHC. C4 plays a centralrole in the activation of the classical pathway of the complement system.Human complement component C4 is polymorphic at two loci, C4A and C4B. TheC4A alleles carry the Rodgers (Rg) while the C4B alleles carry the Chido (Ch)blood group antigens. C4 (either allele A or B) protein is expressed as asingle chain precursor which is proteolytically cleaved into a trimer ofalpha, beta, and gamma chains prior to secretion. The trimer provides asurface for interaction between the antigen-antibody complex and othercomplement components. During activation, the alpha chain is cleaved by C1into C4a and C4b, and C4b stays linked to the beta and gamma chains. Furtherdegradation of C4b by C1 into the inactive fragments C4c and C4d blocks thegeneration of C3 convertase.

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SPECIFICATIONS

Catalog Number

DPAB1836

Hosts

Rabbit

Reactivities

Hum

Conjugates

Unconj

Target

c4

Clonality

Polyclonal

Storage Temp

Store in the dark at2-8oC. Do not use after expiration date stamped on vial. If reagents arestored under any conditions other than those specified, the conditions mustbe verified by the user. There are no obvious signs to indicate instabilityof this product. Therefore, positive and negative controls should be runsimultaneously with patient specimens. During storage a small precipitate mayoccasionally develop causing a fine granular non-specific staining. By asimple filtration (0.22 ?m cellulose acetate filter), theoriginal high quality of the conjugate will be restored. Conjugates shouldnot be stored in diluted form.