Rat anti-Mouse TLR2 monoclonal antibody for FC. The mainfunction of human leucocyte antigen (HLA) molecules is to present antigenicpeptides to the T-cell receptor, thereby regulating the induction of theimmune response. The HLA molecules are encoded by a cluster of tightly linkedgenes located on the short arm of chromosome 6. Three classes of HLAmolecules (I, II and III) have been denoted. Human class II genes are locatedin the HLA-D region, consisting of three families called DQ, DP and DR. Theproducts of class II genes form a heterodimeric transmembrane protein,consisting of a heavy (~34 kDa) ?-chain and a light (~28 kDa) ?-chain. The DR?-chain is expressed from one non-polymorphic gene, whereas the DR ?-chainoriginates from nine highly polymorphic genes. HLA-DR antigen isconstitutively expressed on antigen-presenting cells, such as B lymphocytes,monocytes and dendritic cells but can also be detected on activated Tlymphocytes and activated granulocytes. Occasionally, natural killer cellsexpress HLA-DR antigen. The antigen has been found expressed in cases ofdifferent types of acute lymphoblastic leukaemias, acute myeloid leukaemiasexcept AML-M3, chronic lymphoblastic leukaemias, chronic myeloid leukaemiasand B- and T-cell non-Hodgkin's leukaemias. However, the antigen is normallynotpresenton non-haematopoietic tumours and multiple myelomas.
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Products ![Magic™ Anti-HLA-DR monoclonal antibody, clone BB4 [RPE]](/system/suppliers/default_product_images/000/000/443/main/Creative-Diagnostics-Produc.gif?1438006329)
