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Magic™ Anti-PhosphoY (Phospho Y) monoclonal antibody, clone 14G10

Cat no: DMAB8091


Supplier: Creative Diagnostics
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Mouse Anti-PhosphoY (Phospho Y) monoclonal antibody for ELISA, WB, RIA, FC, IHC, IP. Protein phosphorylation is an important posttranslational modification that serves many key functions to regulate a protein's activity, localization, and protein-protein interactions. Phosphorylation is catalyzed by various specific protein kinases, which involves removing a phosphate group from ATP and covalently attaching it to to a recipient protein that acts as a substrate. Most kinases act on both serine and threonine; others act on tyrosine, and a number (dual specificity kinases) act on all three. Because phosphorylation can occur at multiple sites on any given protein, it can therefore change the function or localization of that protein at any time. Changing the function of these proteins has been linked to a number of diseases, including cancer, diabetes, heart disease, inflammation and neurological disorders In particular, the phosphorylation of tyrosine is considered one of the key steps in signal transduction and regulation of enzymatic activity. Phosphotyrosine can be detected through specific antibodies, and are helpful in facilitating the identification of tyrosine kinase substrates.
Catalogue number: DMAB8091
Hosts: Mouse
Applications: ELISA
Conjugates: Unconjugated
Clone: 14G10
Target: Tyrosine
Isotype: IgG1
Clonality: Monoclonal
Storage temp: -20°C; 1 year+; shipped on cold packs or ambient

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