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MAP Kinase p63 (MAP Kinase Isoform p63, p63-MAPK, p63MAPK, Extracellular Signal-regulated Kinase 4, ERK4, ERK-4, Mitogen-activated Protein Kinase 4, MAP Kinase 4, MAPK 4, MAPK4, PRKM4)

Cat no: M2362-90

MAP Kinase p63 (MAP Kinase Isoform p63, p63-MAPK, p63MAPK, Extracellular Signal-regulated Kinase 4, ERK4, ERK-4, Mitogen-activated Protein Kinase 4, MAP Kinase 4, MAPK 4, MAPK4, PRKM4)

The heterogeneous expression of human MAP (Mitogen Activated Protein) kinase isoforms in differentiated tissues may reflect the diversity of the signal transduction pathways in differentiated cells. MAP kinases also known as erks have been established to function as important mediators of signal transduction by growth factor receptors. Several components of the MAP kinase signal transduction pathway have been demonstrated to be oncogenically activated in malignant tumors. The genes that encode MAP kinases therefore represent potential targets for carcinogenic penetration. These include the p63 MAP kinase (erk-3 related) 18q 12-21 gene loci site.\n\nApplications: \nSuitable for use in Western Blot, Immunoprecipitation, Immunohistochemistry. Other applications not tested.\n\nRecommended Dilution:\nWestern Blot: 5-10ug/ml\nImmunoprecipitation: 5ug/sample\nImmunohistochemistry: 1:10-1:50\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability: \nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

M2362-90

Size

250ug

Applications

IHC, IP, WB

Hosts

Sheep

Reactivities

Hum

Form

Supplied as a liquid in PBS, pH 7.5. No preservative added.

P Type

Pab

Purity

Purified by Protein G affinity chromatography.

Isotype

IgG

References

1. Gonzalez, F.A., et al., FEBS Letters 304: 170 (1992). 2. Li, L., et al., Oncogene 9: 647 (1994).

Additional Info

Recognizes p63 MAP Kinase: 100%.

Alternative Names

EC=2.7.11.24

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