MAP3K8, Recombinant, Mouse, GST-Tag (Cancer Osaka Thyroid Oncogene, Mitogen-activated Protein Kinase Kinase Kinase 8, Proto-oncogene c-Cot, Serine/Threonine-protein Kinase Cot, Cot)

MAP3K8 is required for TLR4 activation of the MEK/ERK pathway. It is able to activate NF-kappa-B 1 by stimulating proteasome-mediated proteolysis of NF-kappa-B 1/p105. It plays a role in the cell cycle.\n\nSource:\nRecombinant corresponding to aa30-397 from mouse MAP3K8, fused to His-GST-tag at N-terminal, expressed in a Baculovirus-infected Sf9 cell expression system.\n\nMolecular Weight:\n~70kD\n\nSpecific Activity:\n~8.5pmole/min/mg\n\nApplications:\nSuitable for use in the study of enzyme kinetics, screening inhibitors, and selectivity profiling. Other applications not tested.\n\nRecommended Dilution:\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nAliquot to avoid repeated freezing and thawing and store at -70 degrees C. Aliquots are stable for 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Prices direct from United States Biological

Quick response times

Exclusive Biosave savings/discounts

SPECIFICATIONS

Catalog Number

137312

Size

10ug

Form

Supplied as a liquid in 40mM Tris-HCl, pH 8.0, 110mM sodium chloride, 2.4mM potassium chloride, 5mM glutathione, 134mM imidazole, 3mM DTT, 20% glycerol.

Purity

Purified (~38%)

References

1. Jeong, J.H. et al., PLoS One. 2011 Jan 18; 6(1):e16205. 2. Soria-Castro, I. et. al. J Biol Chem. 2010 Oct 29;285(44):33805-15.