Home  >  Products  >  Marimastat ((2S,3R)-N4-[(1S)-2,2-Dimethyl-1-[(-[(methylamino)carbonyl]propyl]-N1,2-dihydroxy-3-(2-methylpropyl)butanediamide, BB-2516, TA-2516)
Marimastat ((2S,3R)-N4-[(1S)-2,2-Dimethyl-1-[(-[(methylamino)carbonyl]propyl]-N1,2-dihydroxy-3-(2-methylpropyl)butanediamide, BB-2516, TA-2516)

Marimastat ((2S,3R)-N4-[(1S)-2,2-Dimethyl-1-[(-[(methylamino)carbonyl]propyl]-N1,2-dihydroxy-3-(2-methylpropyl)butanediamide, BB-2516, TA-2516)

Cat no: M2404

Supplier: United States Biological
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A broad spectrum matrix metalloprotease (MMP) inhibitor with IC50 values of 3, 5, 6, 9 and 13 nM for MMP-9, MMP-1, MMP-2, MMP-14 and MMP-7 respectively. It covalently binds to the zinc(II) ion in the active site of MMPs, thereby inhibiting the action of MMPs, inducing extracellular matrix degradation, and inhibiting angiogenesis, tumor growth and invasion, and metastasis. Solubility: DMSO (~100mM) Molecular Weight: ~331.41 Storage and Stability: Lyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with DMSO. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: M2404
Size: 1mg
Form: Supplied as a white solid.
Purity: ~98% (HPLC)
References: 1. Rasmussen, H.S., and McCann, P.P. (1997). Pharmacol. Ther. 75, 69-75.

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