Matrix Metalloproteinases, Colorimetric, BioAssay(TM) Kit

Kit Size 100 Assays (96-well plate)\n\nThis kit is optimized to detect MMP activity and screen for MMP inhibitors. It provides enough reagents to perform 100 assays in a 96-well format.\n\nHigh Speed: The entire process can be completed in minimal time\n\nMatrix metalloproteinases (MMPs) belong to a family of secreted or membrane-associated\nzinc endopeptidases capable of digesting extracellular matrix components and processing bioactive mediators.1,2 Based on their role in normal and pathological processes, including embryogenesis, wound healing, inflammation, arthritis,3 and cancer,4,5 MMPs have been chosen as therapeutic targets for the treatment of many diseases.\n\nThe MMP Assay Kit can be used for the continuous spectrophotometric assay of MMPs activity, including MMP-1, 2, 3, 7, 8, 9, 12, 13, and 14 and for high throughput screening of MMP inducers and inhibitors. The chromogenic substrate is a thiopeptolide that is cleaved by the MMPs, releasing a sulfhydryl group. The sulfhydryl group reacts with Ellman

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SPECIFICATIONS

Catalog Number

M2420-08B

Size

1Kit

Applications

ELISA

References

1. Woessner, J.F. Jr. and CJ. Taplin, J. Biol. Chem. 263, 16918 (1988). 2. Woessner, JF. Jr. FASEB J. 5, 2145 (1991). 3. Gravallese, EM. et al. Arthritis Rheum. 34, 1076 (1991). 4. Stetler-Stevenson, WG. et al. Annu. Rev. Cell Biol. 9, 541 (1993). 5. Goldberg, GI. et al. Ann. NY. Acad. Sci. 580, 375 (1990).