Mcl-1 (S155) Peptide

Mcl1 is an anti-apoptotic member of Bcl2 family originally isolated from the ML1 human myeloid leukemia cell line during phorbol ester-induced differentiation along the monocyte/macrophage pathway. Mcl1 localizes to the mitochondria, interacts with and antagonizes pro-apoptotic Bcl2 family members, and inhibits apoptosis by a number of cytotoxic stimuli. It is involved in programing of differentiation and concomitant maintenance of viability but not of proliferation. Isoform 1 inhibits apoptosis while isoform 2 promotes it. Expression increases early during phorbol-ester induced differentiation along the monocyte/macrophage pathway in myeloid leukemia cell lines ML1.

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SPECIFICATIONS

Catalog Number

BS2642P

Applications

BNI

Form

1 mg/ml in DI water.

Purity

Synthetic peptide Mcl-1 (S155). (Note: the amino acid sequence is proprietary). The purity is > 98%.

Swiss Prot

Q07820

Storage Temp

Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.

Additional Info

This peptide can be used with studies using BS2642 Mcl-1 (S155) pAb.

Alternative Names

Induced myeloid leukemia cell differentiation protein Mcl 1; Myeloid Cell Leukemia 1; BCL2 related; EAT; MCL1L; MCL1S; MGC1839; myeloid cell leukemia sequence 1; TM; MGC104264; MCL 1; Bcl 2 related protein EAT/mcl1; Mcl1/EAT; Myeloid cell leukemia se