The MCP proteins belong to the CC chemokine family, and signal through CCR2 and, with the exception of MCP-1, other CCR receptors. The MCP proteins chemoattract and activate monocytes, activated T cells, basophils, NK cells, and immature dendritic cells. The MCP family cross reacts across species. Recombinant murine JE is a 13.8kD protein containing 125aa including the four highly conserved cysteine residues present in the CC chemokines.
Source:
Recombinant protein corresponding to mouse MCP-1, expressed in E.coli.
Biological Activity:
Determined by its ability to chemoattract Balb/C mouse spleen MNCs using a concentration range of 1-20ng/ml.
Endotoxin:
<0.1ng/ug (1EU/ug)
AA Sequence:
QPDAVNAPLT CCYSFTSKMI PMSRLESYKR ITSSRCPKEA VVFVTKLKRE VCADPKKEWV QTYIKNLDRN QMRSEPTTLF KTASALRSSA PLNVKLTRKS EANASTTFST TTSSTSVGVT SVTVN
Storage and Stability:
May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
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