MDM2 Antibody

Cat no: 251766

Supplier: ABBIOTEC

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Description
Additional Information

MDM2 mediates ubiquitination of p53/TP53, leading to its degration by the proteasome. MDM2 inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding to their respective transcriptional activation domains. MDM2 also acts as an ubiquitin ligase towards itself and ARRB1,Porcineermits the nuclear e, Xenopus/Amphibian,port of TP53/p53, and promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein.

Catalogue number:	251766
Reactivities:	Human, Mouse, Rabbit
Applications:	Immunohistochemistry
Size:	0.1 mg
Accession:	Q00987
Antigen:	KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human MDM2.
Format:	Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 0.2% BSAwith 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
P type:	Mouse Monoclonal Antibody
Isotype:	Mouse IgG1
Additional info:	MDM2; E3 ubiquitin-protein ligase Mdm2; p53-binding protein Mdm2; Oncoprotein Mdm2; Double minute 2 protein; Hdm2