MEK1, 2 Inhibitor (U0126, Bis[amino[(2-aminophenyl)thio]methylene] Butanedinitrile)

Cat no: M2865-50A

Supplier: United States Biological

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Selective inhibitor of the mitogen-activated protein kinase kinases, MEK-1 and MEK-2, with 100-fold higher potency than PD 98059, but is, at most, a weak inhibitor of PKC, Raf, ERK, JNK, MEKK, MKK-3, MKK-4/SEK, MKK-6, Abl, Cdk2 and Cdk4. U0126 is an inhibitor of AP-1 transactivation in cell-based reporter assays. In aqueous and certain organic solvents M2865-50A exists as an equilibrium mixture of 2 isomers which cannot be permanently separated. The 2 individual isomers have equivalent biological activity because they give rise to the same equilibrium mixture of isomes in aqueous solutions. Solubility: Soluble in DMSO at 200mg/ml. Very poorly soluble in ethanol and water. Maximum solubility in plain water is estimated to be about 10-50uM. Melting Point: 156-159C Storage and Stability: May be stored at RT for short-term only. Long-term storage is recommended at -20 degrees C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Catalogue number:	M2865-50A
Size:	25mg
Form:	Supplied as a white powder.
Purity:	~99% (HPLC, TLC)
References:	1. Favata, M.F., et al., J. Biol. Chem. 273: 18,623-18,632 (1998). 2. DeSilva, D.R., et al., J. Immuol. 160: 4175-4181 (1998). 3. Scherle, P.A., et al., J. Immuol. 161: 5681-5686 (1998).

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MEK1, 2 Inhibitor (U0126, Bis[amino[(2-aminophenyl)thio]methylene] Butanedinitrile)

Cat no: M2865-50A

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