MEK1 Inhibitor (PD98059, 2

Potent, selective and cell-permeable inhibitor of MAP kinase kinase (also known as MAPK/ERK kinase or MEK kinase). Inhibits phosphorylation of MAP kinase by MAP kinase kinase. PD 98059 does not inhibit MAP kinase itself. IC50 values for PD 98059-induced effects are in the 1-20uM range for many assays; it is somewhat weaker in inhibiting cell growth in monolayers or agar for some cell lines.\n\nSolubility:\nSoluble in DMSO.\n\nStorage and Stability:\nLyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with DMSO. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

M2865-17C

Size

5mg

Form

Supplied as a pale yellow powder.

Purity

~99%

References

1. Dudley, D.T., et al. \"A synthetic inhibitor of the mitogen-activated protein kinase cascade.\" \"Proc. Natl. Acad. Sci. USA 92:7686-7689 (1995). 2. Pang, L., et al. \"Inhibition of MAP kinase kinase blocks the differentiation of PC-12 cells induced by nerve growth factor.\" J. Biol. Chem. 270:13585-13588 (1995). 3. Waters, S.B., et al. \"Desensitization of Ras activation by a feedback disassociation of the SOS-Grb2 complex.\" J. Biol. Chem. 270:20883-20886 (1995). 4. Langlois, W.J., et al. \"Negative feedback regulation and desensitization of insulin- and epidermal growth factor-stimulated p21ras activation.\" J. Biol. Chem. 270:25320-25323 (1995). 5. Alessi, D.R., et al. \"PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo.\" J. Biol. Chem. 270:27489-27494 (1995).