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MEK1 (Thr386) Antibody
ABBIOTEC

Supplier:

ABBIOTEC

Cat no: 252556

MEK1 (Thr386) Antibody

MEK1 (MAPKK1) catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. MEKI (MAPKK1) activates ERK1 and ERK2 MAP kinases, enzymes which are involved in numerous signal transduction pathways. Defects in MEK1 (MAPKK1) are a cause of cardiofaciocutaneous syndrome (CFC syndrome), also known as cardio-facio-cutaneous syndrome. CFC syndrome is characterized by a distinctive facial appearance, heart defects and mental retardation. The sites on MEK 1 that are phosphorylated by MAP kinase are Thr292 and Thr386.

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SPECIFICATIONS

Catalog Number

252556

Size

0.1 ml

Applications

WB

Reactivities

Hum, Mouse, Bov, Ch/Bird, Rabbit, Xen/Amph

Format

Each vial contains 0.1 ml IgG in HEPES pH7.5, 150 mM NaCl, 0.01% BSA and 50% glycerol. Antibody was purified by immunogen affinity chromatography.

P Type

Rabbit Polyclonal Antibody,Porcinehosphospecific Antibody

Antigen

KLH-conjugated synthetic phosphopeptide encompassing a sequence surrounding Thr386 of human MEK1.

Isotype

Rabbit IgG

Accession

Q02750

Additional Info

MAPKK1; Dual specificity mitogen-activated protein kinase kinase 1; MAP kinase kinase 1; MAPKK1; ERK activator kinase 1; MAPK/ERK kinase 1; MEK1; MAP2K1; PRKMK2

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