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Melanoma, gp100, Control Peptide (95kD Melanocyte Specific Secreted Glycoprotein, D12S53E, ME20, ME20M/ME20S, Melanocyte Lineage Specific Antigen GP100, Melanocyte Protein Mel 17, Melanocyte Protein Pmel 17, Melanoma Associated ME20 Antigen, Melanosomal M

Cat no: M2870-02D

Melanoma, gp100, Control Peptide (95kD Melanocyte Specific Secreted Glycoprotein, D12S53E, ME20, ME20M/ME20S, Melanocyte Lineage Specific Antigen GP100, Melanocyte Protein Mel 17, Melanocyte Protein Pmel 17, Melanoma Associated ME20 Antigen, Melanosomal M

Melanoma gp100 a melanosomal matrix protein whose expression is closely correlated with cellular melanin content and which is a frequent melanoma tumor antigen recognized by cytotoxic T lymphocytes. It is a likely candidate gene for some cases of human oculocutaneous albinism not associated with known albinism loci. The gp100 protein is the most abundant glycoprotein in nucleated mammalian cells. The gp100 antigen is highly expressed in melanocyte cells, and recognized by cytotoxic T lynphocytes. The gp100 protein is known to initiate cellular immune response through the interaction with mature dendritic cells (DCs). GP100/PMel17 is a melanoma differentiation antigen, which is observed as the target of tumor infiltrating lymphocytes (TIL) and has therefore been proposed as an immunotherapeutic agent in malignant melanoma.\n\nSequence: H-Ala-Leu-Asn-Phe-Pro-Gly-Ser-Gln-Lys-OH (ALNFPGSQK)\n\nApplications:\nSuitable for use as a control peptide.\n\nRecommended Dilution:\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nLyophilized powder may be stored at 4 degrees C for short-term only.\nReconstitute to nominal volume (see reconstitution instructions for peptides) and store at -20 degrees C. Reconstituted product is stable for 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

M2870-02D

Size

1mg

Reactivities

Hum

Form

Supplied as a lyophilized powder.

Purity

Highly Purified

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