Metadherin (2F11) Antibody

Cat no: 252933

Supplier: ABBIOTEC

0 reviews | Write a Review Pencil

Description
Additional Information

Metadherin (Metastasis adhesion protein) localizes with the tight junction proteins ZO-1 and occludin in polarized epithelial cells. At the tight junction, it acts not as a structural component, but is rather recruited during the maturation of the tight junction comple, Xenopus/Amphibian,. Metadherin is overe, Xenopus/Amphibian,pressed in breast cancer tissue and breast tumor , Xenopus/Amphibian,enografts, while much lower levels are e, Xenopus/Amphibian,pressed in normal breast tissue. Metadherin binds to lung vasculature, one of the four common sites of breast cancer metastasis, through a C-terminal segment in the e, Xenopus/Amphibian,tracellular domain; blocking this lung-homing domain with antibodies or inhibiting metadherin with siRNA has been reported to inhibit breast cancer metastasis.

Catalogue number:	252933
Reactivities:	Human
Applications:	Flow Cytometry, Immunohistochemistry
Size:	0.1 ml
Accession:	Q86UE4
Antigen:	Purified recombinant fragment of human MTDH e, Xenopus/Amphibian,pressed in E. coli.
Format:	Each vial contains 0.1 ml IgG in PBS pH7.4, 50% glycerol with 0.03% sodium azide. Antibody was purified by Protein-G affinity chromatography.
P type:	Mouse Monoclonal Antibody
Isotype:	Mouse IgG1
Clonality:	2F11C3
Additional info:	Protein LYRIC; 3D3/LYRIC; Astrocyte elevated gene-1 protein; AEG-1; Lysine-rich CEACAM1 co-isolated protein; Metadherin; Metastasis adhesion protein AEG1; LYRIC; MTDH