mGluR1a (Metabotropic Glutamate Receptor)

Cat no: G3500-07A

Supplier: United States Biological

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Metabotropic glutamate receptors (mGluRs) are G-protein coupled receptors activated by glutamate. Based on sequence similarity, transduction mechanisms and agonist potencies, mGluRs are subdivided into three groups: mGluR1/mGluR5, mGluR2/mGluR3, and mGluR4/mGluR6/mGluR7/mGluR8. mGluRs are widely distributed throughout the nervous system and are expressed by both neurons and glial cells. mGluRs have been suggested to play a variety of functional roles, among which is involvement in synaptic plasticity underlying learning and memory as well as chronic pain. Applications: Suitable for use in Western Blot, Immunohistochemistry and Immunocytochemistry. Other applications not tested. Recommended Dilution: Western Blot: 1:1000 Immunohistochemistry: 1:250 Immunocytochemistry: 1:250 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Catalogue number:	G3500-07A
Reactivities:	Human, Mouse, Rat
Hosts:	Rabbit
Applications:	Immunocytochemistry, Immunohistochemistry, Western Blot
Size:	100ul
Form:	Supplied as a liquid in PBS.
P type:	Pab
Isotype:	IgG
Purity:	Purified by immunoaffinity chromatography.
References:	Reid, S. N., Romano, C., Hughes, T., and Daw, N. W. (1995). Immunohistochemical study of two phosphoinositide-linked metabotropic glutamate receptors (mGluR1 alpha and mGluR5) in the cat visual cortex before, during, and after the peak of the critical period for eye-specific connections. J Comp Neurol 355 (3), 470-7.
Additional info:	Recognizes rat mGluR1a. Species Crossreactivity: Human and mouse.

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mGluR1a (Metabotropic Glutamate Receptor)

Cat no: G3500-07A

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