MHC Class 1 Chain-related Gene A, Recombinant, Human (MICA)

MICA (MHC class I chain-related gene A) is a transmembrane glycoprotein that functions as a ligand for human NKG2D. A closely related protein, MICB, shares 85% amino acid identity with MICA. These proteins are distantly related to the MHC class I proteins. They possess three extracellular Ig-like domains, but they have no capacity to bind peptide or interact with 2-microglobulin. The genes encoding these proteins are found within the Major Histocompatibility Complex on human chromosome 6. The MICA locus is highly polymorphic with more than 50 recognized human alleles. MICA is absent from most cells but is frequently expressed in epithelial tumors and can be induced by bacterial and viral infections. MICA is a ligand for human NKG2D, an activating receptor expressed on NK cells, NKT cells, T cells, and CD8+ T cells. Recognition of MICA by NKG2D results in the activation of cytolytic activity and/or cytokine production by these effector cells. MICA recognition is involved in tumor surveillance, viral infections, and autoimmune diseases.\n\nDescription: \nRecombinant Human MICA produced in E.Coli is a single, non-glycosylated polypeptide chain containing 320 amino acids and having a molecular mass of 36kD. The sequence contains the extracellular domain of the mature human MICA (amino acid residues Ala23

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SPECIFICATIONS

Catalog Number

M3886-75

Size

2ug

Form

Supplied as a lyophilized powder without additives.

Purity

(same/more than) 95% as determined by RP-HPLC, anion-exchange FPLC and/or reducing and non-reducing SDS-PAGE Silver Stained gel.

References

1. MHC class I chain-related gene a diversity in head and neck squamous cell carcinoma.\n\nHum Immunol 2006 Mar;67(3):196-203\n\n2. Clinical behavior of multiple sclerosis is modulated by the MHC class I-chain-related gene A.\n\nTissue Antigens 2006 May;67(5):409-14\n\n3. MHC class I chain-related gene A-A5.1 allele is associated with ulcerative colitis in Chinese population.\n\nClin Exp Immunol 2005 Oct;142(1):193-8\n\n4. Assoc iation of MHC class I chain related gene-A microsatellite polymorphism with the susceptibility to T1DM and LADA in Czech adult patients.\n\nInt J Immunogenet 2005 Oct;32(5):273-5\n\n5. MHC class I chain-related gene A (MICA) polymorphism and the different histological types of cervical cancer.\n\nNeoplasma 2005;52(5):369-73\n\n6. Homozygosity for premature stop codon of the MHC class I chain-related gene A (MIC-A) is associated with early activation of islet autoimmunity of DR3/4-DQ2/8 high risk DAISY relatives.\n\nJ Clin Immunol 2005 Jul;25(4):303-8