MHC Class 1 Chain-related Gene B, Recombinant, Human (MICB)

MICB (MHC class I chain-related gene B) is a transmembrane glycoprotein that functions as a ligand for human NKG2D. A closely related protein, MICA, shares 85% amino acid identity with MICB. These 2 proteins are distantly related to the MHC class I proteins. MICA and MICB (MICA/B) possess three extracellular immunoglobulin-like domains, but have no capacity to bind peptide or interact with 2-microglobulin. The genes encoding MICA/B are found within the major histocompatibility complex on human chromosome 6. The MICB locus is polymorphic with more than 15 recognized human alleles. MICA/B are minimally expressed on normal cells, but are frequently expressed on epithelial tumors and can be induced by bacterial and viral infections. MICA/B are ligands for NKG2D, an activating receptor expressed on NK cells, NKT cells, T cells, and CD8+ T cells. Recognition of MICA/B by NKG2D results in the activation of cytolytic activity and/or cytokine production by these effector cells. MICA/B recognition is involved in tumor surveillance, viral infections, and autoimmune diseases. The release of soluble forms of MICA/B from tumors down-regulates NKG2D surface expression on effector cells resulting in the impairment of anti-tumor immune response.\n\nDescription:\nrHuMICB produced in E.Coli is a single, non-glycosylated polypeptide chain containing 326 amino acids and having a molecular mass of 37kD. The sequence contains the extracellular domain of the mature human MICB (amino acid residues Ala23

Prices direct from United States Biological

Quick response times

Exclusive Biosave savings/discounts

SPECIFICATIONS

Catalog Number

M3886-76

Size

2ug

Form

Supplied as a lyophilized powder without additives.

Purity

(same/more than) 95% as determined by RP-HPLC, anion-exchange FPLC and/or reducing and non-reducing SDS-PAGE Silver Stained gel.

References

1. MICA, MICB, and MHC beta block matching in bone marrow transplantation: relevance to transplantation outcome.\n\nHum Immunol 2006 Mar;67(3):238-46\n\n2. Release of MICB molecules by tumor cells: mechanism and soluble MICB in sera of cancer patients.\n\nHum Immunol 2006 Mar;67(3):188-95\n\n3. Introduction: MICA/MICB in innate immunity, adaptive immunity, autoimmunity, cancer, and in the immune response to transplants.\n\nHum Immunol 2006 Mar;67(3):141-4\n\n4. MICB microsatellite polymorphism is associated with ulcerative colitis in Chinese population.\n\nClin Immunol 2006 May 4;\n\n5. Expression of MHC class I-related Chain B (MICB) molecules on renal transplant biopsies.\n\nTransplantation 2006 Apr 27;81(8):1196-203\n\n6. Soluble MICB in malignant diseases: analysis of diagnostic significance and correlation with soluble MICA.\n\nCancer Immunol Immunother 2006 Apr 25;