MIC1, Recombinant, Human (Uncharacterized Protein C18orf8, Colon Cancer-associated Protein Mic1, Mic-1, C18orf8, FLJ23453)

GDF-15 belongs to the TGF-b cytokine family whose members play an important role during prenatal development and postnatal growth, remodeling and maintenance of a variety of tissues and organs. GDF-15 is expressed predominantly in placenta and to a much lesser extent in various other tissues. The presence of GDF-15 in amniotic fluid and its elevated levels in the sera of pregnant women suggest a role for GDF-15 in gestation and embryonic development. GDF-15 generally exerts tumor suppressive activities and is one of the predominant factors produced and secreted in response to activation of the p53 pathway. Interestingly, the serum level of GDF-15 is positively correlated with neoplastic progression of several tumor types, including certain colorectal, pancreatic, and prostate cancers. Human GDF-15/MIC-1 is a disulfide linked homodimeric protein consisting of two 114aa polypeptide chains.\n\nSource:\nRecombinant protein corresponding to human GDF-15/MIC-1, expressed in cell culture.\n\nBiological Activity:\nBiological activity was determined by a cell inhibition assay using DU-145 cells. The expected ED50 for this effect is 1-2ug/ml.\n\nEndotoxin:\n<0.1ng/ug (1EU/ug)\n\nAA Sequence:\nARNGDHCPLG PGRCCRLHTV RASLEDLGWA DWVLSPREVQ VTMCIGACPS QFRAANMHAQ IKTSLHRLKP DTVPAPCCVP ASYNPMVLIQ KTDTGVSLQT YDDLLAKDCH CI\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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